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Immunohistochemical prognostic markers of esophageal squamous cell carcinoma:a systematic review

查看全文 作　　者：Chunni [1]Wang;Jingnan [1]Wang;Zhaoli [1]Chen;Yibo [1]Gao;Jie [1,2]He 高影响力作者 机构地区：[1]Department of Thoracic Surgery, National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Science Building;[2]Center for Cancer Precision Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College高影响力机构 出　　处：《Chinese Journal of Cancer》索引2017年第36卷第11期,共17页高影响力期刊 基　　金：supported by the National Key R&D Program of China (No.2016YFC1303200);the National Natural Science Foundation of China (No. 81502060);Institutional Basic Research Funding (No.NCC2016YKY-06, JK2014B14) 摘　　要：Background: Esophageal squamous cell carcinoma(ESCC) is an aggressive malignancy, with a high incidence and poor prognosis. In the past several decades, hundreds of proteins have been reported to be associated with the prognosis of ESCC, but none has been widely accepted to guide clinical care. This study aimed to identify proteins with great potential for predicting prognosis of ESCC.Methods: We conducted a systematic review on immunohistochemical(IHC) prognostic markers of ESCC according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) Guidelines. Literature related to IHC prognostic markers of ESCC were searched from PubMed, Embase, Web of Science, and Cochrane Library until January 30 th, 2017. The risk of bias of these original studies was evaluated using the Quality in Prognosis Studies(QUIPS) tool.Results: We identified 11 emerging IHC markers with reproducible results, including eight markers [epidermal growth factor receptor(EGFR), Cyclin D1, vascular endothelial growth factor(VEGF), Survivin, Podoplanin, Fascin,phosphorylated mammalian target of rapamycin(p-mTOR), and pyruvate kinase M2(PKM2)] indicating unfavorable prognosis and 3 markers(P27, P16, and E-cadherin) indicating favorable prognosis of ESCC.Conclusion: Strong evidence supports that these 11 emerging IHC markers or their combinations may be useful in predicting prognosis and aiding personalized therapy decision-making for ESCC patients. 关 键 词：ESOPHAGEAL SQUAMOUS cell carcinoma Prognosis SURVIVAL IMMUNOHISTOCHEMICAL MARKERS
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