Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs

查看全文 作　　者：Hakhyun [1]Ka;Heewon [1,2]Seo;Yohan [1,3]Choi;Inkyu [1]Yoo;Jisoo [1]Han

机构地区：[1]Department of Biological Science and Technology, Yonsei University;[2]Department of Veterinary Integrated Biosciences,Texas A&M University, College Station;[3]Department of Obstetrics and Gynecology, University of Kentucky College of Medicine

出　　处：《Journal of Animal Science and Biotechnology》索引2018年第9卷第3期,共17页

基　　金：Support for the work from the authors’laboratory described in this review paper has been provided by the Bio Green 21 Program(200506030501;20070301034040; 20080401034003; PJ007997; PJ009610; PJ01110301;PJ01119103);the Rural Development Administration;a National Research Foundation grant funded by the Korean Government(KRF-2005-003-F00017,KRF-2007-521-F00030,NRF-2010-0012304,NRF-2010-10012304; NRF-2012R1A2A2A01047079; NRF-2015R1D1A1A01058356,Republic of Korea 摘　　要：The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs. 关键词：CONCEPTUS ENDOMETRIUM ESTROGEN INTERLEUKIN-1Β Pig UTERUS

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Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs

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