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Clinical impact of microbiome in patients with decompensated cirrhosis

查看全文 作　　者：Theodora [1]Oikonomou;George V [2]Papatheodoridis;Michael [3]Samarkos;Ioannis [1]Goulis;Evangelos [3]Cholongitas 高影响力作者 机构地区：[1]Fourth Department of Internal Medicine, Hippokration General Hospital, Medical School of Aristotle University of Thessaloniki;[2]Academic Department of Gastroenterology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens;[3]First Department of Internal Medicine, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens高影响力机构 出　　处：《World Journal of Gastroenterology》索引2018年第24卷第34期,共8页高影响力期刊 摘　　要：Cirrhosis is an increasing cause of morbidity and mortality. Recent studies are trying to clarify the role of microbiome in clinical exacerbation of patients with decompensated cirrhosis. Nowadays, it is accepted that patients with cirrhosis have altered salivary and enteric microbiome, characterized by the presence of dysbiosis. This altered microbiome along with small bowel bacterial overgrowth, through translocation across the gut, is associated with the development of decompensating complications. Studies have analyzed the correlation of certain bacterial families with the development of hepatic encephalopathy in cirrhotics. In general, stool and saliva dysbiosis with reduction of autochthonous bacteria in patients with cirrhosis incites changes in bacterial defenses and higher risk for bacterial infections, such as spontaneous bacterial peritonitis, and sepsis. Gut microbiome has even been associated with oncogenic pathways and under circumstances might promote the development of hepatocarcinogenesis. Lately, the existence of the oral-gutliver axis has been related with the development of decompensating events. This link between the liver and the oral cavity could be via the gut through impaired intestinal permeability that allows direct translocation of bacteria from the oral cavity to the systemic circulation. Overall, the contribution of the microbiome to pathogenesis becomes more pronounced with progressive disease and therefore may represent an important therapeutic target in the management of cirrhosis. 关 键 词：MICROBIOME DYSBIOSIS Oral-gut-liver axis Hepatic ENCEPHALOPATHY DECOMPENSATED cirrhosis LIVER carcinoma
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