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Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus:a retrospective cohort study

查看全文 作　　者：Patrícia dos Santos [1]Marcon;Cristiane Valle [1]Tovo;Dimas Alexandre [2]Kliemann;Patrícia [3]Fisch;Angelo Alves de [1]Mattos 高影响力作者 机构地区：[1]Hepatology Post-Graduate Program,Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA),Porto Alegre 90020-090,RS,Brazil;[2]Infectology Department at Hospital Nossa Senhora da Conceicao,Porto Alegre 91350-200,RS,Brazil;[3]Epidemiology Department at Hospital Nossa Senhora da Conceicao,Porto Alegre 91350-200,RS,Brazil高影响力机构 出　　处：《World Journal of Gastroenterology》索引2018年第24卷第5期,共10页高影响力期刊 摘　　要：AIM To assess the incidence of hepatocellular carcinoma(HCC) in chronic liver disease due to hepatitis B virus(HBV) or hepatitis C virus(HCV) coinfected with human immunodeficiency virus(HIV).METHODS A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014. We assessed demographic and clinical data, including lifestyle habits such as illicit drug use or alcohol abuse, in addition to frequency and reasons for hospital admissions via medical records review.RESULTS Of 804 patients were included(399 with HIV coinfection and 405 monoinfected with HBV or HCV). Coinfected patients were younger(36.7 ± 10 vs 46.3 ± 12.5, P < 0.001). Liver cirrhosis was observed in 31.3% of HIV-negative patients and in 16.5% of coinfected(P < 0.001). HCC was diagnosed in 36 patients(10 HIV coinfected and 26 monoinfected). The incidence density of HCC in coinfected and monoinfected patients was 0.25 and 0.72 cases per 100 patient-years(95%CI: 0.12-0.46 vs 0.47-1.05)(long-rank P = 0.002), respectively. The ratio for the HCC incidence rate was 2.98 for HIV-negative. However, when adjusting for age or when only cirrhotic are analyzed, the absence of HIV lost statistical significance for the development of HCC. CONCLUSION In this study, the presence of HIV coinfection in chronic liver disease due to HBV or HCV showed no relation to the increase of HCC incidence. 关 键 词：HEPATOCELLULAR carcinoma Chronic HEPATITIS human IMMUNODEFICIENCY virus COINFECTION CIRRHOSIS
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