Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin

查看全文 作　　者：Paula [1]Mantero;Gonzalo Sebastián [2]Matus;Rodolfo Ernesto [2]Corti;Ana María [3]Cabanne;Gerardo Gabriel Zerbetto de [1,4]Palma;Liliana Marchesi [5]Olid;María Marta [6]Piskorz;Marcela Beatriz [7]Zubillaga;Mariana Andrea [1]Janjetic;Cinthia Gabriela [1]Goldman

机构地区：[1]Universidad de Buenos Aires,Facultad de Farmacia y Bioquímica,Cátedra de Física,Buenos Aires C1113AAD,Argentina;[2]Hospital de Gastroenterología“Dr.Carlos Bonorino Udaondo”,Sección Esófago-Estómago,Buenos Aires C1264AAA,Argentina;[3]Hospital de Gastroenterología'Dr.Carlos Bonorino Udaondo”,Unidad Patología,Buenos Aires C1264AAA,Argentina;[4]Universidad de Buenos Aires-CONICET,Facultad de Medicina,Instituto de Microbiología y Parasitología Médica(IMPAM),Buenos Aires C1121ABG,Argentina;[5]Universidad de Buenos Aires,Facultad de Medicina,Escuela de Nutrición,Buenos Aires C1121ABG,Argentina;[6]Hospital de Clínicas“Joséde San Martín”,División Gastroenterología,Buenos Aires C1120AAR,Argentina;[7]National Scientific and Technical Research Council(CONICET),Buenos Aires C1425FQB,Argentina

出　　处：《World Journal of Gastroenterology》索引2018年第24卷第3期,共11页

基　　金：the Universidad de Buenos Aires (UBA), Buenos Aires, Argentina, No. UBACYT 20020100100837 and No. UBACYT 20020130100645BA to Goldman CG;the International Atomic Energy Agency (IAEA), Vienna, Austria, Coordinated Research Project (CRP) E43025 No. ARG-16746 to Goldman CG. UBA 摘　　要：AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. 关键词：HELICOBACTER PYLORI CAGA GHRELIN Leptin Pathology

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Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin

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