Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

查看全文 作　　者：Yan-Lan [1]Fang;Hong [2]Chen;Chun-Lin [1]Wang;Li [1]Liang

机构地区：[1]Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University;[2]College of Medicine, Zhejiang University

出　　处：《World Journal of Gastroenterology》索引2018年第24卷第27期,共10页

基　　金：Supported by The National Key Research and Development Program of China,No.2016YFC1305301 摘　　要：Nonalcoholic fatty liver disease(NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver-which generally follows a benign, non-progressive clinical course-to non-alcoholic steatohepatitis, a subset of NAFLD that may progress to cirrhosis and end-stage liver disease or liver carcinoma. The underlying pathophysiological mechanism of 'pediatric' NAFLD remains unclear, although it is strongly associated with obesity and insulin resistance. In this review we provide a general overview on the current understanding of NAFLD in children and adolescents, which underpins practice, enabling early diagnosis and appropriate therapeutic intervention for this life-threatening liver disease. 关键词：Non-alcoholic STEATOHEPATITIS CHILDREN Adolescents PATHOGENESIS NONALCOHOLIC fatty liver disease

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Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

参考文献(105)

引证文献(133)

耦合文献(38)

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