From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

查看全文 作　　者：Maria Gloria [1]Mumolo;Lorenzo [2]Bertani;Linda [1]Ceccarelli;Gabriella [2]Laino;Giorgia Di [1]Fluri;Eleonora [2]Albano;Gherardo [2]Tapete;Francesco [1]Costa

机构地区：[1]Department of General Surgery and Gastroenterology, Gastroenterology Unit, Azienda Ospedaliero Universitaria Pisana;[2]Department of New Technologies and Translational Research in Medicine and Surgery, University of Pisa

出　　处：《World Journal of Gastroenterology》索引2018年第24卷第33期,共14页

摘　　要：Fecal calprotectin(FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases(IBD). Many different methods of assessment have been developed and different cutoffs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome(IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. In IBD patients a correlation with both mucosal healing and histology was found, and there is increasing evidence that FC assessment can be helpful in monitoring disease activity and response to therapy as well as in predicting relapse, post-operative recurrence or pouchitis. Recently, its use in the context of a treat-to-target approach led to a better outcome than clinically-based therapy adjustment in patients with early Crohn's disease. In conclusion, FC measurement represents a cheap, safe and reliable test, easy to perform and with a good reproducibility. The main concerns are still related to the choice of the optimal cut-off, both for differentiating IBD from IBS, and for the management of IBD patients. 关键词：FECAL CALPROTECTIN inflammatory BOWEL diseases Crohn’s disease ULCERATIVE colitis IRRITABLE BOWEL syndrome

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From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

参考文献(115)

引证文献(10)

耦合文献(32)

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