Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data

查看全文 作　　者：Manish [1]Chand;Deborah S [2]Keller;Reza [3]Mirnezami;Marc [4]Bullock;Aneel [5]Bhangu;Brendan [6]Moran;Paris P [7]Tekkis;Gina [8]Brown;Alex [9]Mirnezami;Mariana [10]Berho

机构地区：[1]GENIE Centre,University College London,London W1W 7TS,United Kingdom;[2]Department of Surgery,Columbia University Medical Centre,New York,NY 10032,United States;[3]Department of Surgery,Imperial College London,London SW7 2AZ,United Kingdom;[4]Department of Surgery,University of Southampton,Southampton SO17 1BJ,United Kingdom;[5]Department of Surgery,University of Birmingham,Birmingham B15 2QU,United Kingdom;[6]Department of Colorectal Surgery,North Hampshire Hospital,Basingstoke RG24 7AL,United Kingdom;[7]Department of Colorectal Surgery,Royal Marsden Hospital and Imperial College London,London SW3 6JJ,United Kingdom;[8]Department of Radiology,Royal Marsden Hospital and Imperial College London,London SW3 6JJ,United Kingdom;[9]Department of Surgical Oncology,University of Southampton and NIHR,Southampton SO17 1BJ,United Kingdom;[10]Department of Pathology,Cleveland Clinic Florida,Weston,FL 33331,United States

出　　处：《World Journal of Gastrointestinal Oncology》索引2018年第10卷第7期,共14页

摘　　要：Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. 关键词：BIOMARKER COLORECTAL cancer Epithelial-tomesenchymal-transition pathway Molecular BIOMARKER MicroRNA METABOLIC BIOMARKER Imaging BIOMARKER TUMOUR regression grade

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Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data

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