Vitamin D in esophageal cancer: Is there a role for chemoprevention?

查看全文 作　　者：Carol [1]Rouphael;Afrin [2]Kamal;Madhusudhan R [2]Sanaka;Prashanthi N [2]Thota

机构地区：[1]Department of Internal Medicine,Cleveland Clinic;[2]Department of Gastroenterology and Hepatology,Cleveland Clinic

出　　处：《World Journal of Gastrointestinal Oncology》索引2018年第10卷第1期,共8页

摘　　要：Vitamin D has emerged as a promising anti-cancer agent due to its diverse biological effects on tumor differentiation, apoptosis and suppression of cellular proliferation. Current evidence suggests a protective role of vitamin D in colon cancer. The effect of vitamin D on esophageal cancer remains controversial. Multiple studies investigated the association between vitamin D and esophageal cancer, employing different modes of assessment of vitamin D status such as serum 25-hydroxyvitamin D levels, vitamin D dietary intake or exposure to ultraviolet B(UVB) radiation. Genetic variations of the vitamin D receptor(VDR) gene and VDR expression in esophageal specimens have also been investigated. Ecological studies evaluating exposure to UVB radiation yielded an inverse correlation with esophageal cancer. When vitamin D dietary intake was assessed, direct association with esophageal cancer was observed. However, circulating 25-hydroxyvitamin D concentrations showed inconsistent results. In this review article, we present a detailed summary of the current data on the effects of vitamin D on various histological subtypes of esophageal cancer and their precursor lesions. Well-powered prospective studies with accurate measurement of vitamin D status are needed before chemoprevention with vitamin D is recommended, as current evidence does not support a chemopreventive role of vitamin D against esophageal cancer. Future studies looking at the incidence of esophageal cancer in patients with pre-cancerous lesions(Barrett's esophagus and squamous cell dysplasia) receiving vitamin D supplementation are needed. 关键词：VITAMIN D VITAMIN D receptor ESOPHAGEAL ADENOCARCINOMA ESOPHAGEAL SQUAMOUS cell carcinoma genetic polymorphism

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Vitamin D in esophageal cancer: Is there a role for chemoprevention?

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