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Role of inflammatory response in liver diseases: Therapeutic strategies

查看全文 作　　者：José A Del [1]Campo;Paloma [1]Gallego;Lourdes [1]Grande 高影响力作者 机构地区：[1]Department of Digestive Diseases, Valme University Hospital and CIBERehd高影响力机构 出　　处：《World Journal of Hepatology》索引2018年第10卷第1期,共7页高影响力期刊 基　　金：Supported by Andalusian Government,No.PI0892-2012;Instituto de Salud Carlos III,PI14/01349 co-financed by the European Regional Development Fund(ERDF);JA Del Campo supported by Nicolás Monardes Program from Servicio Andaluz de Salud(SAS) 摘　　要：Inflammation and tumorigenesis are tightly linked pathways impacting cancer development. Inflammasomes are key signalling platforms that detect pathogenic microorganisms, including hepatitis C virus(HCV) infection, and sterile stressors(oxidative stress, insulin resistance, lipotoxicity) able to activate pro-inflammatory cytokines interleukin-1β and IL-18. Most of the inflammasome complexes that have been described to date contain a NOD-like receptor sensor molecule. Redox state and autophagy can regulate inflammasome complex and, depending on the conditions, can be either pro-or antiapoptotic. Acute and chronic liver diseases are cytokinedriven diseases as several proinflammatory cytokines(IL-1α, IL-1β, tumor necrosis factor-alpha, and IL-6) are critically involved in inflammation, steatosis, fibrosis, and cancer development. NLRP3 inflammasome gain of function aggravates liver disease, resulting in severe liver fibrosis and highlighting this pathway in the pathogenesis of non-alcoholic fatty liver disease. On the other hand, HCV infection is the primary catalyst for progressive liver disease and development of liver cancer. It is well established that HCV-induced IL-1β production by hepatic macrophages plays a critical and central process that promotes liver inflammation and disease. In this review, we aim to clarify the role of the inflammasome in the aggravation of liver disease, and how selective blockade of this main pathway may be a useful strategy to delay fibrosis progression in liver diseases. 关 键 词：Caspase-1 Fibrosis Hepatitis C virus INFLAMMASOME INTERLEUKIN-1Α INTERLEUKIN-1Β LIVER DISEASE Non-alcoholic fatty LIVER DISEASE NLRP3 Tumor necrosis FACTOR-ALPHA
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