Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis

查看全文 作　　者：Andrea Dória [1,2]Batista;Carlos Jonnatan Pimentel [3]Barros;Tássia Brena Barroso Carneiro [3]Costa;Michele Maria Goncalves de [4]Godoy;Ronaldo Dionísio [3]Silva;Joelma Carvalho [1]Santos;Mariana Montenegro de Melo [5]Lira;Norma [5]ThoméJucá;Edmundo Pessoa de Almeida [1,2]Lopes;Ricardo Oliveira [3]Silva

机构地区：[1]Postgraduate Program in Tropical Medicine,Center for Health Sciences,Universidade Federal de Pernambuco,Recife,Pernambuco 50670-901,Brazil;[2]Department of Gastroenterology and Hepatology,Hospital das Clínicas,Universidade Federal de Pernambuco,Recife,Pernambuco 50670-901,Brazil;[3]Department of Fundamental Chemistry,Center for Exact and Nature Sciences,Universidade Federal de Pernambuco,Recife,Pernambuco 50670-901,Brazil;[4]Intensive Care Unit,Hospital das Clínicas,Universidade Federal de Pernambuco,Recife,Pernambuco 50670-901,Brazil;[5]Department of Pathology,Hospital das Clínicas,Universidade Federal de Pernambuco,Recife,Pernambuco 50670-901,Brazi

出　　处：《World Journal of Hepatology》索引2018年第10卷第1期,共11页

基　　金：the Brazilian funding agencies CNPq;FACEPE 摘　　要：AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. 关键词：Metabolomics Nuclear magnetic resonance spectroscopy Chronic HEPATITIS C Liver FIBROSIS Surrogate MARKERS

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Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis

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