Chronic obstructive pulmonary disease as a risk factor for lung cancer

查看全文 作　　者：Yuichi [1]Takiguchi;Ikuo [1]Sekine;Shunichiro [1]Iwasawa;Ryota [1]Kurimoto;Koichiro [2]Tatsumi

机构地区：[1]Department of Medical Oncology, Graduate School of Medicine, Chiba University;[2]Department of Respirology, Graduate School of Medicine, Chiba University

出　　处：《World Journal of Clinical Oncology》索引2014年第5卷第4期,共7页

基　　金：Supported by The Ministry of Education,Culture,Sports,Science and Technology of Japan 摘　　要：The association between chronic obstructive pulmonary disease(COPD) and lung cancer has long been a subject of intense debate. The high prevalence of COPD in elderly smokers inevitably strengthens their coincidence. In addition to this contingent coincidence, recent studies have revealed a close association between the two diseases that is independent of the smoking history; that is, the existence of COPD is an independent risk factor for the development of lung cancer. Molecular-based evidence has been accumulating as a result of the efforts to explain the underlying mechanisms of this association. These mechanisms may include the following: the retention of airborne carcinogens followed by the activation of oncogenes and the suppression of tumor suppressor genes; the complex molecular mechanism associated with chronic inflammation in the distal airways of patients with COPD; the possible in-volvement of putative distal airway stem cells; and gel netic factors that are common to both COPD and lung cancer. The existence of COPD in patients with lung l cancer may potentially affect the process of diagnosis, surgical resection, radiotherapy, chemotherapy, and end-of-life care. The comprehensive management of COPD is extremely important for the appropriate treatment of lung cancer. Surgical resections with the aid of early interventions for COPD are often possible, even for patients with mild-to-moderate COPD. New challenges, such as lung cancer CT screening for individuals t at high risk, are now in the process of being implemented. Evaluating the risk of lung cancer in patients with COPD may be warranted in community-based lung cancer screening. 关键词：Chronic OBSTRUCTIVE pulmonary disease Airflow limitation Inflammation Lung CANCER CARCINOGENESIS CANCER SCREENING Computed tomography SCREENING Early intervention

相关文献

参考文献（60）
引证文献（22）
耦合文献（0）

参考文献(60)

引证文献(22)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Chronic obstructive pulmonary disease as a risk factor for lung cancer

参考文献(60)

引证文献(22)

用户提示