Short and long term prognosis in perinatal asphyxia: An update

查看全文 作　　者：Caroline E [1,2]Ahearne;Geraldine B [1,2]Boylan;Deirdre M [1,2]Murray

机构地区：[1]Department of Paediatrics and Child Health, University College Cork;[2]Irish Centre for Fetal and Neonatal Translational Research (INFANT Centre), University College Cork

出　　处：《World Journal of Clinical Pediatrics》索引2016年第5卷第1期,共8页

基　　金：Supported by The Health Research Board CSA/2012/40;a Science Foundation Ireland Research Centre Award(INFANT-12/RC/2272) 摘　　要：Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to neonatal encephalopathy(NE) and resultant long-term damage. While the majority of infants who are exposed to perinatal hypoxia-ischaemia will recover quickly and go on to have a completely normal survival, a proportion will suffer from an evolving clinical encephalopathy termed hypoxic-ischaemic encephalopathy(HIE) or NE if the diagnosis is unclear. Resultant complications of HIE/NE are wide-ranging and may affect the motor, sensory, cognitive and behavioural outcome of the child. The advent of therapeutic hypothermia as a neuroprotective treatment for those with moderate and severe encephalopathy has improved prognosis. Outcome prediction in these infants has changed, but is more important than ever, as hypothermia is a time sensitive intervention, with a very narrow therapeutic window. To identify those who will benefit from current and emerging neuroprotective therapies we must be able to establish the severity of their injury soon after birth. Currently available indicators such as blood biochemistry, clinical examination and electrophysiology are limited. Emerging biological and physiological markers have the potential to improve our ability to select those infants who will benefit most from intervention. Biomarkers identified from work in proteomics, metabolomics and transcriptomics as well as physiological markers such as heart rate variability, EEG analysis and radiological imaging when combined with neuroprotective measures have the potential to improve outcome in HIE/NE. The aim of this review is to give an overview of the literature in regards to short and longterm outcome following perinatal asphyxia, and to discuss the prediction of this outcome in the early hours after birth when intervention is most crucial; looking at both currently available tools and introducing novel markers. 关键词：PERINATAL ASPHYXIA NEUROLOGICAL outcome Hypoxic ISCHAEMIC ENCEPHALOPATHY Cerebral PALSY Cognitive

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Short and long term prognosis in perinatal asphyxia: An update

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