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Current views of the relationship between Helicobacter pylori and Henoch-Schonlein purpura in children

查看全文 作　　者：Li-Jing [1]Xiong;Meng [2,3]Mao 高影响力作者 机构地区：[1]Department of Gastroenterology and Hepatology,Chengdu Women and Children’s Central Hospital;[2]Chengdu Women and Children’s Central Hospital;[3]Department of Pediatrics, West China Second University Hospital高影响力机构 出　　处：《World Journal of Clinical Pediatrics》索引2016年第5卷第1期,共7页高影响力期刊 摘　　要：Helicobacter pylori(H. pylori) is one of the factors involved in the pathogenesis of various gastrointestinal diseases and may play a potential role in certain extraintestinal diseases. H. pylori infection are mainly acquired during childhood, and it has been reported that in endemic areas of China the infection rates are extraordinarily higher in HSP children, particular those with abdominal manifestations. Furthermore, eradication therapy may ameliorate Henoch-Schonlein purpura(HSP) manifestations and decrease the recurrence of HSP. Therefore, results suggested that detection of H. pylori infection by appropriate method ought to be applied in HSP children. Current evidences indicate that local injury of gastric mucosa and immunological events induced by H. pylori infection are involved in the development of HSP. Increased serum Ig A, cryoglobulins, C3 levels, autoimmunity, proinflammatory substances and molecular mimicry inducing immune complex and cross-reactive antibodies caused by H. pylori infection might play their roles in the course of HSP. However, there are no investigations confirming the causality between H. pylori infection and HSP, and the pathogenesis mechanism is still unclear. More bench and clinical studies need to be executed to elaborate the complex association between H. pylori and HSP. 关 键 词：HELICOBACTER PYLORI Henoch-Schonlein PURPURA CHILDREN
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