Acute encephalitis and encephalopathy associated with human parvovirus B19 infection in children

查看全文 作　　者：Toru [1]Watanabe;Hideshi [1]Kawashima

机构地区：[1]Department of Pediatrics,Niigata City General Hospital

出　　处：《World Journal of Clinical Pediatrics》索引2015年第4卷第4期,共9页

摘　　要：Reports of neurologic manifestations of human parvovirus B19(B19) infection have been on the rise. Acute encephalitis and encephalopathy is the most common, accounting for 38.8% of total B19-associated neurological manifestations. To date, 34 children with B19encephalitis and encephalopathy have been reported, which includes 21 encephalitis and 13 encephalopathy cases. Ten(29%) were immunocompromised and 17(39%) had underlying diseases. Fever at the onset of disease and rash presented in 44.1% and 20.6% of patients, respectively. Neurological manifestations include alteration of consciousness occurred in all patients, seizures in 15(44.1%) patients, and focal neurologic signs in 12(35.3%) patients. Anemia and pleocytosis in cerebrospinal fluid(CSF) occurred in 56.3% and 48.1% of patients, respectively. Serum Anti-B19 Ig M(82.6%) and CSF B19 DNA(90%) were positive in the majority of cases. Some patients were treated with intravenous immunoglobulins and/or steroids, although an accurate evaluation of the efficacy of these treatment modalities cannot be determined. Nineteen(57.6%) patients recovered completely, 11(33.3%) patients had some neurological sequelae and 3(8.8%) patients died. Although the precise pathogenesis underlying the development of B19 encephalitis and encephalopathy is unclear, direct B19 infection or NS1 protein of B19 toxicity in the brain, and immune-mediated brain injuries have been proposed. 关键词：ENCEPHALITIS NEUROLOGICAL MANIFESTATION Human PARVOVIRUS B19 ENCEPHALOPATHY Pathogenesis Complication

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Acute encephalitis and encephalopathy associated with human parvovirus B19 infection in children

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