Platelets:A possible glance into brain biological processes in schizophrenia

查看全文 作　　者：Eyal [1]Asor;Dorit Ben-[1]Shachar

机构地区：[1]Laboratory of Psychobiology,Department of Psychiatry,Rambam Medical Center and B.Rappaport Faculty of Medicine,Rappaport Family Institute for Research in the Medical Sciences,Technion,PO Box 9649,Haifa 31096,Israel

出　　处：《World Journal of Psychiatry》索引2012年第2卷第6期,共10页

摘　　要：Schizophrenia is a severe mental disorder, characterized by behavioral, emotional and cognitive disturbances,which commonly follows a chronic course. Diagnostic accuracy, management plans, treatment evaluation and prognosis are dependent on relatively subjective assessments. Despite extensive research and improvement in imaging technology, as well as modern genetic and molecular methodologies, the biological basis of this disease is still unclear. Therefore, there is a need for objective and valid biological markers. Platelets have often been used as a model in neurobiological research. The accessibility of platelets and their similarities with neurons turns them into an attractive candidate to search for biological markers for diagnosis and for unraveling pathophysiological processes relevant to the etiology of brain disorders, including schizophrenia.The present review addresses the main changes in platelet physiology observed in schizophrenia and its response to antipsychotic medication. We summarize numerous studies demonstrating impaired metabolism,uptake and receptor kinetics of schizophrenia-relevantneurotransmitters, abnormalities in membrane derived phospholipids and polyunsaturated fatty acids, as well as dysfunctions in the mitochondria. These changes fit with the various hypotheses raised for the etiology of schizophrenia, including the dopamine-glutamate hypothesis, the autoimmune hypothesis, the polyunsaturated fatty acid hypothesis and the impaired energy metabolism hypothesis. Despite extensive research in platelets, no conclusive reliable biomarker has been identified yet. This review suggests that the clinical heterogeneity and the biological complexity of schizophrenia lead to the inevitable conclusion that biomarkers will be identified only for subgroups characterized according to the different diagnostic criteria. Moreover, any biomarker would have to be an array of interrelated factors or even a set of several such arrays. 关键词：PLATELETS SCHIZOPHRENIA Biomarkers

相关文献

参考文献（112）
引证文献（3）
耦合文献（0）

参考文献(112)

引证文献(3)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Platelets:A possible glance into brain biological processes in schizophrenia

参考文献(112)

引证文献(3)

用户提示