Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study

查看全文 作　　者：Decebal [1]Fodor;Ioan [1]Jung;Sabin [1]Turdean;Catalin [1]Satala;Simona [1,2]Gurzu

机构地区：[1]Department of Pathology, University of Medicine,Pharmacy, Sciences and Technology;[2]Research Center (CCAMF), University of Medicine, Pharmacy, Sciences and Technology

出　　处：《World Journal of Hepatology》索引2019年第11卷第3期,共11页

摘　　要：BACKGROUND Although hepatocellular carcinoma(HCC) is one of the most vascular solid tumors, antiangiogenic therapy has not induced the expected results.AIM To uncover immunohistochemical(IHC) aspects of angiogenesis in HCC.METHODS A retrospective cohort study was performed and 50 cases of HCC were randomly selected. The angiogenesis particularities were evaluated based on the IHC markers Cyclooxygenase-2(COX-2), vascular endothelial growth factor(VEGF) A and the endothelial area(EA) was counted using the antibodies CD31 and CD105.RESULTS The angiogenic phenotype evaluated with VEGF-A was more expressed in small tumors without vascular invasion(pT1), whereas COX-2 was rather expressed in dedifferentiated tumors developed in non-cirrhotic liver. The CD31-related EA value decreased in parallel with increasing COX-2 intensity but was higher in HCC cases developed in patients with cirrhosis. The CD105-related EA was higher in tumors developed in patients without associated hepatitis.CONCLUSION In patients with HCC developed in cirrhosis, the newly formed vessels are rather immature and their genesis is mediated via VEGF. In patients with non-cirrhotic liver, COX-2 intensity and number of mature neoformed vessels increases in parallel with HCC dedifferentiation. 关键词：HEPATOCELLULAR carcinoma ANGIOGENESIS ENDOTHELIAL area ANTIANGIOGENIC therapy

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Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study

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