Herbal decoctosome is a novel form of medicine

查看全文 作　　者：Xiaoyun [1]Li;Zhu [1]Liang;Jianchao [1]Du;Zhiqing [1]Wang;Song [1]Mei;Zhiqing [1]Li;Yan [1]Zhao;DANDan [1]Zhao;Yiming [1]Ma;Jun [1]Ye;Jiantao [1]Xu;Yu [1]Zhao;Jiahui [1]Chang;Yuhao [1]Qin;Lanlan [2]Yu;Chenxuan [2]Wang;Chengyu [1]Jiang

机构地区：[1]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College;[2]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biophysics and Structural Biology, Peking Union Medical College

出　　处：《Science China(Life Sciences)》索引2019年第62卷第3期,共16页

基　　金：supported by the National Natural Science Foundation of China (81788101);the Ministry of Science and Technology of China (2015CB553406);the National Natural Science Foundation of China (81490531);the CAMS Innovation Fund for Medical Sciences (2017-I2M-1-009) 摘　　要：Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. 关键词：decoctosome bencaosome SPHINGANINE

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Herbal decoctosome is a novel form of medicine

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