Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain

查看全文 作　　者：Samuele [1,2]Iesari;Milton Eduardo Inostroza Nú?[3]ez;Juan Manuel Rico [4]Juri;Olga [1]Ciccarelli;Eliano Bonaccorsi-[1]Riani;Laurent [1]Coubeau;Pierre-Fran?ois [5]Laterre;Pierre [6]Goffette;Chantal De [1]Reyck;Beno?t [7]Lengelé;Pierre [8]Gianello;Jan [1]Lerut

机构地区：[1]Starzl Abdominal Transplant Unit, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain;[2]Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila;[3]Hepatobiliopancreatic Unit, Las Higueras Hospital;[4]Cirugía de Trasplantes, Centro Médico Imbanaco;[5]Department of Intensive Care, Cliniques Universitaires Saint-Luc, Université catholique de Louvain;[6]Department of Radiology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain;[7]Department of Plastic and Reconstructive Surgery, Cliniques Universitaires Saint-Luc, Université catholique de Louvain;[8]P?le de Chirurgie Expérimentale et Transplantation, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain

出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2019年第18卷第2期,共11页

摘　　要：Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. 关键词：LIVER transplantation Living-donor Hepatocellular cancer Secondary LIVER tumor Small-for-size syndrome Small-for-size GRAFT

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Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain

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