Small molecule activators of the p53 response

查看全文 作　　者：Marcus [1,2]J.G.W.Ladds;Sonia [1,2]Lain

机构地区：[1]Department of Microbiology,Tumor and Cell Biology,Biomedicum,Solnavagen 9,Karolinska Institutet,17165,Stockholm,Sweden;[2]SciLifeLab,Tomtebodavagen 23A,171 65,Soina,Stockholm,Sweden

出　　处：《Journal of Molecular Cell Biology》索引2019年第11卷第3期,共10页

摘　　要：Drugging the p53 pathway has been a goal for both academics and pharmaceutical companies since the designation of p53 as the'guardian of the genome'.Through growing understanding of p53 biology,we can see multiple routes for activation of both wild-type p53 function and restoration of mutant p53?In this review,we focus on small molecules that activate wild-type p53 and that do so in a nongenotoxit manner.In particular,we will describe potential approaches to targeting proteins that alter p53 stability and function through posttranslational modification,affect p53's subcellular localization,or target RNA synthesis or the synthesis of ribonucleotides.The plethora of pathways for exploitation of p53,as well as the wide-ranging response to p53 activation,makes it an attractive target for anti-cancer therapy. 关键词：CANCER P53 small MOLECULE cell BIOLOGY CANCER THERAPY

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Small molecule activators of the p53 response

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