Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

查看全文 作　　者：Shilei [1]ZHENG;Jingru [1]ZHU;Jiao [1]LI;Shuang [1]ZHANG;Yunfei [1]MA

机构地区：[1]College of Veterinary Medicine, China Agricultural University

出　　处：《Frontiers of Agricultural Science and Engineering》索引2019年第6卷第2期,共9页

基　　金：supported by the National Natural Science Foundation of China(31772686 and 31502025);the Public Service Sectors Agriculture Research Projects of Ministry of Agriculture of China(201403051-07) 摘　　要：The present study was designed to investigate the protective effects of leonurine, a compound purified from Herba Leonuri that is active on ischemic rat behavior and cortical neurons, and explore the underlying mechanism. The general rat activity, cortical neuron morphology, superoxide dismutase (SOD), malondialdehyde (MDA),γ- aminobutyric acid (GABA) and glutamate decarboxylase 67 (GAD67) levels were measured. We found leonurine significantly improve the general activity of rats in an opefield test, which was associated with attenuated neuronal damage induced by ischemia. Moreover, serum SOD activity was significantly greater, MDA level lower in the leonurine group as compared with ischemia group. In addition, GABA content in the cerebral cortex was significantly greater in high-dose leonurine group. Correspondingly, GAD67 protein level coincided with the GABA level. Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative and anti-excitotoxicity effects by targeting GABA and leonurine might become a useful adjuvant neuroprotective agent. 关键词：cerebral ISCHEMIA GABA NEUROPROTECTION LEONURINE SOD

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Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

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