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Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms

查看全文 作　　者：Lingling [1,2]Cui;Fei [1,3,4]Wang;Miao [1,4]Chang;Zhiyang [3,4]Yin;Guoguang [1]Fan;Yanzhuo [3,4]Song;Yange [3,4]Wei;Yixiao [3,4]Xu;Yifan [3,4]Zhang;Yanqing [3,4,5]Tang;Xiaohong [2]Gong;Ke [1]Xu 高影响力作者 机构地区：[1]Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;[2]State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China;[3]Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;[4]Brain Function Research Section, The First Affiliated Hospital of China Medical University, Shenyang 110001, China;[5]Department of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang 110001, China高影响力机构 出　　处：《Neuroscience Bulletin》索引2019年第35卷第4期,共8页高影响力期刊 基　　金：supported by the National Basic Research Development Program of China (2016YFC0906400, 2016YFC1306900 and 2016YFC0904300);the National Natural Science Foundation of China (81571311 and 81571331);the National Science Fund for Distinguished Young Scholars of China (81725005);the National High Tech Development Project (863 Project) of China (2015AA020513);the Science and Technology Project of Liaoning Province, China (2015225018);the Educational Foundation (Pandeng Scholarship) of Liaoning Province, China;the support of Department of Radiology and Psychiatry, First Affiliated Hospital of China Medical University 摘　　要：ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.However,the neural mechanisms underlying this association are unknown.Given that ZNF804A upregulates the expression of COMT,we hypothesized that ZNF804 A may influence brain activity by interacting with COMT.Here,we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants.Amplitudes of low-frequency fluctuations(ALFFs)were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680.The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 x COMT rs4680 interaction,manifesting as a U-shaped modulation,presumably by dopamine signaling.Significant main effects were also found.These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT,and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia. 关 键 词：Zinc finger protein 804A CATECHOL-O-METHYLTRANSFERASE AMPLITUDES of LOW-FREQUENCY FLUCTUATIONS fMRI
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