Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

查看全文 作　　者：Johanna [1,2]Waidhauser;Anne [1]Bornemann;Martin [2]Trepel;Bruno [1]Markl

机构地区：[1]Institute of Pathology and Molecular Diagnostics,University Medical Center Augsburg,Augsburg 86156,Germany;[2]Department of Hematology and Clinical Oncology,University Medical Center Augsburg,Augsburg 86156,Germany

出　　处：《World Journal of Gastroenterology》索引2019年第25卷第30期,共17页

摘　　要：BACKGROUND In recent years,increasing evidence of second neoplasms associated with gastrointestinal stromal tumors(GIST)has been found.Numerous case reports,mostly retrospective studies and a few reviews,have been published.To our knowledge,however,no systematic review or meta-analysis of the existing data has been performed so far.AIM To prepare a compilation,as complete as possible,of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency,localization,and types of GIST-associated neoplasms.METHODS The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary,synchronous,coincident/tumor,neoplasm,and relevant publications were selected by two independent authors.RESULTS Initially,3042 publications were found.After deletion of duplicates,1631 remained,and 130 papers were selected;22 of these were original studies with a minimum of 20 patients,and 108 were case reports.In the 22 selected studies,comprising a total number of 12050 patients,an overall rate of GIST-associated neoplasias of 20%could be calculated.Most second neoplasias were found in the gastrointestinal tract(32%)and in the male and female urogenital tract(30%).The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated neoplasias.CONCLUSION In this first systematic review,we could confirm previously reported findings of a more than coincidental association between GIST and other neoplasias.The question whether there is an underlying causal association will need further investigation.Our data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging. 关键词：GASTROINTESTINAL STROMAL TUMOR ASSOCIATED Secondary NEOPLASIA TUMOR

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Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

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