Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways

查看全文 作　　者：MAO [1]Lei;WANG [1]Yiming;WANG [1]Meiling;DAI [1]Yufeng;WANG [1]Jingfeng;XUE [1]Changhu

机构地区：[1]College of Food Science and Engineering, Ocean University of China

出　　处：《Journal of Ocean University of China》索引2019年第18卷第5期,共11页

基　　金：financially supported by the National Natural Science Foundation of China (No. 31371876) 摘　　要：The present study investigated the anti-osteoporosis function and the mechanism of sialoglycoproteins isolated from the eggs of Gadus morhua(Gm-SGP)on ovariectomized(OVX)rats.After 3 months of Gm-SGP treatment,OVX-induced bone loss was suppressed and uncoupling bone turnover was balanced,as indicated by systemic biomarkers of bone metabolism;no uterine estrogenicity was observed.Moreover,rats administered with Gm-SGP exhibited increased bone mineral density and biomechanical strength and significant restoration of the trabecular microarchitecture compared with rats in the control group.Gm-SGP significantly decreased bone resorption-related indicators in serum.Investigation of the associated mechanisms revealed that Gm-SGP significantly increases the OPG/RANKL ratio at the mRNA and protein levels.Further research suggested that Gm-SGP inhibits the mRNA and protein expressions of important transcription factors of the MAPK and NF-κB signaling pathways.It also attenuates the activation of related transduction signaling pathways by inhibiting phosphorylation of JNK,ERK,p38,and NF-κB,and ultimately suppresses the induction of c-Fos and NFATc1.Overall,these results demonstrate that Gm-SGP inhibits bone resorption by suppressing osteoclastogenesis-related MAPK and NF-κB pathways,thereby improving osteoporosis. 关键词：Sialoglycoprotein OSTEOPOROSIS MAPKS NF-κB BONE RESORPTION

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Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways

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