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Cerebrospinal fluid neurogranin as a new player in prion disease diagnosis and prognosis

查看全文 作　　者：Anna Villar-[1,2]Piqué;Inga [3,4]Zerr;Franc [1,2,3]Llorens 高影响力作者 机构地区：[1]Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED),Institute Carlos III,Ministry of Health,Hospitalet de Llobregat,Spain;[2]Bellvitge Biomedical Research Institute (IDIBELL),Hospitalet de Llobregat,Spain;[3]Department of Neurology,Clinical Dementia Center and National Reference Center for CJD Surveillance,University Medical School,Gotingen,Germany;[4]German Center for Neurodegenerative Diseases (DZNE),Gotingen,Germany高影响力机构 出　　处：《Neural Regeneration Research》索引2020年第15卷第5期,共2页高影响力期刊 基　　金：funded by the Spanish Ministry of Health-Instituto Carlos Ⅲ(Miguel Servet programme-CP/00041) to FL 摘　　要：Neurogranin (Ng) and its role as Alzheimer’s disease (AD) biomarker: Ng is a calmodulin-binding protein mainly expressed in cerebral structures such as the cortex,hippocampus and striatum.It is mainly located in the dendritic processes,particularly in post-synaptic compartments,but also in the cytosolic compartment,being likely involved in the regulation of the intracellular calcium-calmodulin signaling pathway (Represa et al.,1990).In the last decade,a plethora of studies have demonstrated that cerebrospinal fluid (CSF) Ng is increased in AD patients and in individuals with an ADlike CSF profile (Kester et al.,2015a).This increase seems to be disease-specific because other neurodegenerative conditions including frontotemporal dementia,Lewy body dementia,Parkinson’s disease,progressive supranuclear palsy,multiple system atrophy or Huntington’s disease,present CSF Ng concentrations similar to controls (Wellington et al.,2016).Ng levels in CSF appear to be elevated in mild cognitive impairment (MCI)-affected individuals who progress to AD and are highly related to memory and cognitive function (Kester et al.,2015a;Tarawneh et al.,2016),which indicates that this protein may serve as an early AD biomarker with diagnostic utility in pre-dementia disease stages,and with prognostic utility to predict cognitive decline and MCI-to-AD conversion. 关 键 词：Represa CEREBROSPINAL FLUID MULTIPLE system
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