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Recent advances in molecular fluorescent probes for organic phosphate biomolecules recognition

查看全文 作　　者：Wei [1]Li;Xiangyang [1]Gong;Xiaopeng [1]Fan;Shulu [1]Yin;Dongdong [1]Su;Xiaobing [1]Zhang;Lin [2]Yuan 高影响力作者 机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China;[2]Department of Chemistry and Chemical Engineering,Beijing University of Technology,Beijing 100124,China高影响力机构 出　　处：《Chinese Chemical Letters》索引2019年第30卷第10期,共16页高影响力期刊 基　　金：financially supported by the National Natural Science Foundation of China (NSFC) (Nos. 21622504, 21735001, and 21877029);the Science and Technology Project of Hunan Province (No. 2017RS3019);the Open Funding Project of the State Key Laboratory of Bioreactor Engineering 摘　　要：Organic phosphate biomolecules(OPBs) are indispensable components of eukaryotes and prokaryotes,such as acting as the fundamental components of cell membranes and important substrates for nucleic acids. They play pivotal roles in various biological processes, such as energy conservation, metabolism,and signal modulation. Due to the difficulty of detection caused by variety OPBs, investigation of their respective physiological effects in organisms has been restrained by the lack of efficient tools. Many small fluorescent probes have been employed for selective detection and monitoring of OPBs in vitro or in vivo due to the advantages of tailored properties, biodegradability and in situ high temporal and spatial resolution imaging. In this review, we summarize the recent advances in fluorescent probes for OPBs,such as nucleotides, NAD(P)H, FAD/FMN and PS. Importantly, we describe their identification mechanisms in detail and discuss the general strategies for these OPBs probe designs, which provide new insights and ideas for the future probe designs. 关 键 词：ORGANIC PHOSPHATE biomolecules (OPBs) FLUORESCENT probes SELECTIVE detection FLUORESCENT imaging Design strategies
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