维普中文期刊产品整合服务

In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect

查看全文 作　　者：Junxiu [1,2]Chen;Jiahui [1,2]Dong;Huameng [1]Fu;Haifeng [1]Zhang;Lili [1]Tan;Dewei [3]Zhao;Ke [1]Yang 高影响力作者 机构地区：[1]Institute of Metal Research,Chinese Academy of Sciences,Shenyang,110016,China;[2]School of Materials Science and Engineering,University of Science and Technology of China,Shenyang,110016,China;[3]Department of Orthopedics,Affiliated Zhongshan Hospital of Dalian University,Dalian,J16001,China高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2019年第35卷第10期,共9页高影响力期刊 基　　金：financially supported by the Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement (Nos. 2016YFC1101804 and 2016YFC1100604);the Shenyang Key Research & Development and Technology Transfer Program (No. Z18-0-027) 摘　　要：In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank’s solution. In vitro cytotoxicity test showed that Mg69Zn27Ca4 metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original φ6 mm to φ3.35 ± 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. 关 键 词：Mg69Zn27Ca4 METAL GLASS Degradation CYTOCOMPATIBILITY BONE SUBSTITUTES
相关文献

参考文献(40)

引证文献(5)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费