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Similarities and differences in clinical and pathologic features of inflammatory bowel disease-associated colorectal cancer in China and Canada

查看全文 作　　者：Ji [1]Li;Wei-Xun [2]Zhou;Shuang [1]Liu;Wei-Yang [1]Zheng;Ya-Nan [1]Wang;Jing-Nan [1]Li;Jose Gp [3]Ferraz;Jia-Ming [1]Qian;Xian-Yong [4,5]Gui 高影响力作者 机构地区：[1]Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;[2]Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;[3]Division of Gastroenterology,University of Calgary,Calgary,Alberta,Canada;[4]Department of Pathology and Laboratory Medicine,University of Calgary Cummings School of Medicine,and Calgary Laboratory Services,Calgary,Canada;[5]Department of Pathology,University of Washington School of Medicine,Seattle,USA高影响力机构 出　　处：《Chinese Medical Journal》索引2019年第22期,共6页高影响力期刊 摘　　要：Background:Colorectal cancer(CRC)has become one of the major life-threatening complications in patients with inflammatory bowel disease(IBD),which includes ulcerative colitis(UC)and Crohn's disease(CD).This study aimed to explore the clinicalpathologic similarities and differences in the IBD-associ吐ed CRC(IBD-CRC)between patients in China and Canada.Methods:Data of 78 patients with IBD-CRC retrospectively retrieved from two representative medical institutions in Beijing(China)and Calgary(Canada)over the same past 13 years,including 25(22 UC-associated and three CD-associated)from Beijing group and 53(32 UC-associated and 21 CD-associated)from Calgary group,were compared with regards to their clinical and pathologic characteristics.Results:Several known features of IBD-CRC were seen in both groups,including long duration and large extent of colitis,active inflammation background,multifocal lesions,and advanced tumor-node-metastasis stage.Beijing group showed a significantly higher percentage of UC(88.0%vs.60.4%,P=0.018),younger age at diagnosis of CRC(48.6±12.8 years vs.61.6±14.7 years,P<0.001),lower ratio of mucinous adenocarcinoma(7.1%us.42.4%,P=0.001)compared with Calgary group.None of the Beijing group had concurrent primary sclerosing cholangitis,while 5.7%of Calgary group did.Surveillance colonoscopy favored the detection rate of precancerous lesions(41.4%vs.17.0%,P=0.002).Conclusions:As compared with patients from the Calgary group,the IBD-CRC patients in Beijing group were younger,less CDassociated and had less mucinous features,otherwise they were similar in many common features. 关 键 词：Colitis-associated colorectal cancer Comparative study Crohn's DISEASE Inflammatory bowel DISEASE ULCERATIVE COLITIS
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