Autophagy in bone homeostasis and the onset of osteoporosis

查看全文 作　　者：Xing [1]Yin;Chenchen [1]Zhou;Jingtao [1]Li;Renkai [1]Liu;Bing [1]Shi;Quan [1]Yuan;Shujuan [1]Zou

机构地区：[1]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University

出　　处：《Bone Research》索引2019年第7卷第4期,共16页

基　　金：supported by grants from National Natural Science Foundation of China (81722014, 81801019);the Sichuan Provincial Science and Technology Department (2018JY0139, 2019JDRC0099, 2019YJ0101);the China Postdoctoral Science Foundation (2018M640929);Sichuan University (2018SCU12020);West China Hospital of Stomatology Sichuan University (WCHS-201702) 摘　　要：Autophagy is an evolutionarily conserved intracellular process,in which domestic cellular components are selectively digested for the recycling of nutrients and energy.This process is indispensable for cell homeostasis maintenance and stress responses.Both genetic and functional studies have demonstrated that multiple proteins involved in autophagic activities are critical to the survival,differentiation,and functioning of bone cells,including osteoblasts,osteocytes,and osteoclasts.Dysregulation at the level of autophagic activity consequently disturbs the balance between bone formation and bone resorption and mediates the onset and progression of multiple bone diseases,including osteoporosis.This review aims to introduce the topic of autophagy,summarize the understanding of its relevance in bone physiology,and discuss its role in the onset of osteoporosis and therapeutic potential. 关键词：HOMEOSTASIS OSTEOPOROSIS AUTOPHAGY

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Autophagy in bone homeostasis and the onset of osteoporosis

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引证文献(39)

耦合文献(659)

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