POLIII-derived non-coding RNAs acting as scaffolds and decoys

查看全文 作　　者：[1]HendrikTauber;Stefan [1]Huttelmaier;Marcel [1,2]Kohn

机构地区：[1]Institute of Molecular Medicine,Section for Molecular Cell Biology,Faculty of Medicine,Martin Luther University Halle-Wittenberg,Charles Tan ford Protein Centre,Kurt-Mothes-Str.3a,06120 Halle,Germany;[2]Julius Bernstein Institute of Physiology,Faculty of Medicine,Martin Luther University Halle-Wittenberg,Charles Tan ford Protein Centre,Kurt-Mothes-Str.3a,06120 Halle,Germany

出　　处：《Journal of Molecular Cell Biology》索引2019年第11卷第10期,共6页

摘　　要：A large variety of eukaryotic small structured POLIII-derived non-coding RNAs(ncRNAs)have been described in the past.However,for only few,e.g.7SL and H1/MRP families,cellular functions are well understood.For the vast majority of these transcripts,cellular functions remain unknown.Recent findings on the role ofY RNAs and other POLIII-derived ncRNAs suggest an evolutionarily conserved function of these ncRNAs in the assembly and function of ribonucleoprotein complexes(RNPs).These RNPs provide cellular‘machineries’,which are essential for guiding the fate and function of a variety of RNAs.In this review,we summarize current knowledge on the role of POLIII-derived ncRNAs in the assembly and function of RNPs.We propose that these ncRNAs serve as scaffolding factors that‘chaperone’RNA-binding proteins(RBPs)to form functional RNPs.In addition or associated with this role,some small ncRNAs act as molecular decoys impairing the RBP-guided control of RNA fate by competing with other RNA substrates.This suggests that POLIII-derived ncRNAs serve essential and conserved roles in the assembly of larger RNPs and thus the control of gene expression by indirectly guiding the fate of mRNAs and IncRNAs. 关键词：NCRNA POLIII RBP scaffold RBP DECOY

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POLIII-derived non-coding RNAs acting as scaffolds and decoys

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