维普中文期刊产品整合服务

Disturbed bone remodelling activity varies in different stages of experimental, gradually progressive apical periodontitis in rats

查看全文 作　　者：Ruoshi [1]Xu;Daimo [1]Guo;Xuedong [1]Zhou;Jianxun [1]Sun;Yachuan [1]Zhou;Yi [1]Fan;Xin [2]Zhou;Mian [1]Wan;Wei [1]Du;Liwei [2]Zheng 高影响力作者 机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Cariology and Endodontology,West China Hospital of Stomatology,Sichuan University,Chengdu,China;[2]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Pediatrics,West China Hospital of Stomatology,Sichuan University,Chengdu,China高影响力机构 出　　处：《International Journal of Oral Science》索引2019年第11卷第4期,共11页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(Grant No.81371136)to X.Z.;National Natural Science Foundation of China(Grant No.81771033)to L.Z 摘　　要：Bone remodelling keeps going through the lifespan of human by bone formation and bone resorption.In the craniofacial region,mandibles act as the main force for biting and chewing,and also become susceptible to a common bone-loss disease,namely,apical periodontitis,once infected dental pulp is not treated timely,during which bone resorption occurs from the apical foramen to the apical bone area.Although conventional root canal treatment(RCT)can remove the most of the infection,chronical apical periodontitis due to incomplete removal of dental pulp and subsequent microleakage will become refractory and more challenging,and this process has scarcely been specifically studied as a bone remodelling issue in rat models.Therefore,to study chronical and refractory apical periodontitis owing to incomplete cleaning of infected dental pulp and microleackage in vivo,we establish a modified rat model of gradually progressive apical periodontitis by sealing residual necrotic dental pulp and introducing limited saliva,which simulates gradually progressive apical periodontitis,as observed in the clinical treatment of chronical and refractory apical periodontitis.We show that bone-loss is inevitable and progressive in this case of apical periodontitis,which confirms again that complete and sound root canal treatment is crucial to halt the progression of chronical and refractory apical periodontitis and promote bone formation.Interestingly,bone remodelling was enhanced at the initial stage of apical periodontitis in this model while reduced with a high osteoblast number afterwards,as shown by the time course study of the modified model.Suggesting that the pathological apical microenvironment reserve its hard tissue formation ability to some degree but in a disturbed manner.Hopefully,our findings can provide insights for future bone regenerative treatment for apical periodontitisassociated bone loss. 关 键 词：INCOMPLETE MODELLING PROGRESSIVE
相关文献

参考文献(47)

引证文献(3)

耦合文献(57)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费