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Virus-Mediated Overexpression of ETS-1 in the Ventral Hippocampus Counteracts Depression-Like Behaviors in Rats

查看全文 作　　者：Hanjiang [1]Luo;Zijin [1]Liu;Bo [1]Liu;Hui [2]Li;Yutao [1]Yang;Zhi-Qing David [1]Xu 高影响力作者 机构地区：[1]Department of Neurobiology,Beijing Key Laboratory of Neural Regeneration and Repair,Beijing Laboratory of Major Brain Disorders(Ministry of Science and Technology),Beijing Institute for Brain Disorders,Capital Medical University,Beijing 100069,China;[2]Department of Anatomy,Capital Medical University,Beijing 100069,China高影响力机构 出　　处：《Neuroscience Bulletin》索引2019年第35卷第6期,共10页高影响力期刊 基　　金：supported by grants from the National Natural Science Foundation of China (31271154, 31171032, and 81671345);the Beijing Natural Science Foundation (7162016);the Special Project on Natural Chronic Non-infectious Diseases (2016YFC1307202);the Beijing Municipal Science and Technology Commission (Z181100001518001) 摘　　要：ETS-1 is a transcription factor that is a member of the E26 transformation-specific(ETS) family. Galanin receptor 2(Gal R2), a subtype of receptors of the neuropeptide galanin, has been shown to have an antidepressant-like effect after activation in rodents. Our previous study has shown that overexpression of ETS-1 increases the expression of Gal R2 in PC12 phaeochromocytoma cells. However, whether ETS-1 has an antidepressant-like effect is still unclear. In this study, we found that chronic mild stress(CMS) decreased the expression of both ETS-1 and Gal R2 in the ventral hippocampus of rats. Meanwhile,we demonstrated that overexpression of ETS-1 increased the expression of Gal R2 in primary hippocampal neurons.Importantly, we showed that overexpression of ETS-1 in the ventral hippocampus counteracted the depression-like behaviors of CMS rats. Furthermore, we found that overexpression of ETS-1 increased the level of downstream phosphorylated extracellular signal-regulated protein kinases 1 and 2(p-ERK1/2) of Gal R2 in the ventral hippocampus of CMS rats. Taken together, our findings suggest that ETS-1 has an antidepressant-like effect in rats,which might be mediated by increasing the level of Gal R2 and its downstream p-ERK1/2 in the ventral hippocampus. 关 键 词：Gal R2 ETS-1 DEPRESSION Chronic mild stress
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