维普中文期刊产品整合服务

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

查看全文 作　　者：LUO Ting-[1,2]ting;LU [1,2]Yuan;YAN Shi-[3]kai;XIAO [1,2]Xue;RONG Xiang-[1,2]lu;GUO [1,2]Jiao 高影响力作者 机构地区：[1]Institute of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;[2]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine,Guangzhou 510006,China;[3]School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China高影响力机构 出　　处：《Chinese Journal of Integrative Medicine》索引2020年第26卷第1期,共9页高影响力期刊 基　　金：Supported by the National Natural Science Foundation of China(No.81530102);Guangdong Provincial Science and Technology Agency Special Funds(No.2017B050504005);Guangzhou City Science and Technology Agency Special Funds(No.201803010069) 摘　　要：Chinese medicine(CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula. 关 键 词：network pharmacology Chinese medicine formula targets discovery mechanism research quality control research
相关文献

参考文献(104)

引证文献(266)

耦合文献(572)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费