维普中文期刊产品整合服务

Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma

查看全文 作　　者：Jiangqiao [1,2]Geng;Yuanhu [3]Liu;Yongli [3]Guo;Huanmin [4]Wang;Jun [2]Tai;Yaqiong [3]Jin;Jie [2]Zhang;Yongbo [3]Yu;Shengcai [2]Wang;Yingluan [1]Song;Xin [2,3]Ni 高影响力作者 机构地区：[1]Otolaryngology,Children's Hospital of Hebei Province,Shijiazhuang 050031,China;[2]Otolaryngology,Head and Neck Surgery,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China;[3]Beijing Key Laboratory for Pediatric Diseases of Otolaryngology,Head and Neck Surgery,Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,National Center for Childrens Health,Beijing 100045,China;[4]Department of Surgical Oncology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China高影响力机构 出　　处：《Science China(Life Sciences)》索引2019年第62卷第12期,共9页高影响力期刊 基　　金：supported in part by Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201508);Beijing Municipal Science and Technology Project (D131100005313014);Beijing Health System Top Level Health Technical Personnel Training Plan (20153079);Key subjects of medical science research in Hebei Province (20170395) 摘　　要：The aims of the present study were to reveal the prevalence of the TERT C228 T mutation in pediatric papillary thyroid carcinoma(PPTC) and to further investigate the role of the TERT C228 T mutation in PPTC. We also tested another TERT mutation, TERT C250 T, although this was not detected in PPTC patients. In this study, 48 patients with PPTC(41 with classic PPTC) were enrolled. DNA was extracted from PPTC tissues and TERT C228 T mutation analysis was performed. Chi-squared analysis,Fisher’s exact test, and a t-test were applied to test the significance of differences. The TERT C228 T mutation presented in 13(27.1%) of the 48 PPTC patients and 10(24.4%) of the 41 classical PPTC patients. There were significant differences between PPTC patients with the TERT C228 T mutation and those without in terms of modified radical neck dissection, multifocality,capsular invasion, extrathyroidal invasion, and American Joint Committee on Cancer(AJCC) tumor stage(P<0.05). In classical PPTC, there were additional significant differences in other clinic-pathological features, such as AJCC nodal stage(P=0.009)and American Thyroid Association(ATA) PPTC stage(P=0.021) between patients with and without the TERT C228 T mutation.These findings indicate that the TERT C228 T mutation is significantly correlated with certain aggressive clinic-pathological features of PPTC. 关 键 词：pediatric papillary thyroid cancer TERT C228T mutation clinic-pathological characteristics
相关文献

参考文献(52)

引证文献(3)

耦合文献(12)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费