Comprehensive review into the challenges of gastrointestinal tumors in the Gulf and Levant countries

查看全文 作　　者：Rare Tumors GI [1]Group;Fadi [2]Farhat;Abdulaziz Al [3]Farsi;Ahmed [4]Mohieldin;Bassim Al [3]Bahrani;Eman [5]Sbaity;Hassan [6]Jaffar;Joseph [7]Kattan;Kakil [8]Rasul;Khairallah [9]Saad;Tarek [10]Assi;Waleed El [11]Morsi;Rafid A [12]Abood 机构地区：[1]不详;[2]Hammoud Hospital UMC,Saida PO Box 652,Lebanon;[3]Medical Oncology Department,Royal Hospital,Muscat PO Box 1331,Oman;[4]Medical Oncology Department,Kuwait Cancer Control Center,Kuwait PO Box 42262,Kuwait;[5]Division of General Surgery,American University of Beirut,Beirut 11072180,Lebanon;[6]Oncology Department,Tawam Hospital,Al Ain PO Box 15258,United Arab Emirates;[7]Hemato-oncology Department,Hotel Dieu de France,Beirut,Lebanon;[8]Hemato-oncology Department,National Center for Cancer Care and Research,Doha,Qatar;[9]Pathology Department,Institute National de Pathologic,Beirut,Lebanon;[10]Oncology Department,Faculty of Medicine,Saint-Joseph University,Beirut,Lebanon;[11]Pfizer Oncology-Emerging Markets,Dubai Media City,Dubai,United Arab Emirates;[12]Oncology Department,Basra College of Medicine,Basra,Iraq 出　　处：《World Journal of Clinical Cases》索引2020年第8卷第3期,共17页 摘　　要：Although gastrointestinal stromal tumors(GISTs)are rare,with an incidence of 1/100000 per year,they are the most common sarcomas in the peritoneal cavity.Despite considerable progress in the diagnosis and treatment of GIST,about half of all patients are estimated to experience recurrence.With only two drugs,sunitinib and regorafenib,approved by the Food and Drug Administration,selecting treatment options after imatinib failure and coordinating multidisciplinary care remain challenging.In addition,physicians across the Middle East face some additional and unique challenges such as lack of published local data from clinical trials,national disease registries and regional scientific research,limited access to treatment,lack of standardization of care,and limited access to mutational analysis.Although global guidelines set a framework for the management of GIST,there are no standard local guidelines to guide clinical practice in a resource-limited environment.Therefore,a group of 11 experienced medical oncologists from across the Gulf and Levant region,part of the Rare Tumors Gastrointestinal Group,met over a period of one year to conduct a narrative review of the management of GIST and to describe regional challenges and gaps in patient management as an essential step to proposing local clinical practice recommendations. 关 键 词：Gastrointestinal stromal tumors DIAGNOSIS Disease management Treatment CHALLENGES Middle East