Post-transplantation lymphoproliferative disorders:Current concepts and future therapeutic approaches

查看全文 作　　者：Fedaey [1,2]Abbas;Mohsen El [2,3]Kossi;Ihab Sakr [2,4]Shaheen;Ajay [2,5]Sharma;Ahmed [2,6]Halawa

机构地区：[1]Nephrology Department,Jaber El Ahmed Military Hospital,Safat 13005,Kuwait;[2]Faculty of Health and Science,University of Liverpool,Institute of Learning and Teaching,School of Medicine,Liverpool L693GB,United Kingdom;[3]Doncaster Royal Infirmary,Doncaster DN25LT,United Kingdom;[4]Department of Paediatric Nephrology,Royal Hospital for Children,Glasgow G514TF,United Kingdom;[5]Department of Transplant Surgery,Royal Liverpool University Hospitals,Liverpool L78XP,United Kingdom;[6]Department of Transplantation,Sheffield Teaching Hospitals,Sheffield S57AU,United Kingdom

出　　处：《World Journal of Transplantation》索引2020年第10卷第2期,共18页

摘　　要：Transplant recipients are vulnerable to a higher risk of malignancy after solid organ transplantation and allogeneic hematopoietic stem-cell transplant.Posttransplant lymphoproliferative disorders(PTLD)include a wide spectrum of diseases ranging from benign proliferation of lymphoid tissues to frank malignancy with aggressive behavior.Two main risk factors of PTLD are:Firstly,the cumulative immunosuppressive burden,and secondly,the oncogenic impact of the Epstein-Barr virus.The latter is a key pathognomonic driver of PTLD evolution.Over the last two decades,a considerable progress has been made in diagnosis and therapy of PTLD.The treatment of PTLD includes reduction of immunosuppression,rituximab therapy,either isolated or in combination with other chemotherapeutic agents,adoptive therapy,surgical intervention,antiviral therapy and radiotherapy.In this review we shall discuss the prevalence,clinical clues,prophylactic measures as well as the current and future therapeutic strategies of this devastating disorder. 关键词：Lymphoproliferative disorders Epstein-Barr virus Solid organ transplant Hematopoietic stem cell transplant Post-transplant lymphoproliferative disorder prevention Future therapies

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Post-transplantation lymphoproliferative disorders:Current concepts and future therapeutic approaches

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