Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson’s disease

查看全文 作　　者：Eunju [1]Leem;Sang Ryong [1,2]Kim

机构地区：[1]School of Life Sciences,BK21 plus KNU Creative BioResearch Group,Kyungpook National University,Daegu,Korea;[2]Brain Science and Engineering Institute,Kyungpook National University,Daegu,Korea

出　　处：《Neural Regeneration Research》索引2020年第15卷第10期,共2页

基　　金：supported by a grant from the National Research Foundation of Korea(NRF-2020R1A2C2007954) 摘　　要：Biological roles of astrocyte elevated gene-1(AEG-1):AEG-1,also known as metadherin,was originally identified as a human immunodeficiency virus-1-and tumor necrosis factor-alpha-inducible gene in human fetal astrocytes.The increase in AEG-1 expression is a well-established and important oncogenic event in various types of human cancer,and its upregulation triggers evasion of cellular apoptosis,metastasis,and invasion in cancer(Emdad at al.,2016;Dhiman et al.,2019).AEG-1 can promote tumor progression via multiple phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)pathways,contributing to an invasive phenotype and angiogenesis(Emdad at al.,2016;Dhiman et al.,2019).In addition,there is evidence for a functional link between AEG-1 and pro-survival mechanisms in various cancers(Dhiman et al.,2019),suggesting that AEG-1 is a key molecule for oncogenic events in cancer. 关键词：ELEVATED al. INVASION

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Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson’s disease

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