Neurosurgical treatment for addiction:lessons from an untold story in China and a path forward

查看全文 作　　者：Shuo [1]Ma;Chencheng [1]Zhang;Ti-fei [2,3]Yuan;Douglas [4]Steele;Valerie [1,5]Voon;Bomin [1]Sun

机构地区：[1]Department of Functional Neurosurgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;[2]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;[3]Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China;[4]Division of Imaging Science and Technology,Medical School,University of Dundee,Dundee DD14HN,UK;[5]Department of Psychiatry,University of Cambridge,Cambridge CB20SZ,UK

出　　处：《National Science Review》索引2020年第7卷第3期,共11页

基　　金：the National Key Research and Development Program of China(2017YFC0803607 to C.-C.Z.);Shanghai Science and Technology Committee(18410710400 to B.-M.S.,18QA1403700 to T.-F.Y.);the National Natural Science Foundation of China(81822017 and 31771215);Shanghai JiaoTongUniversity School of Medicine-Institution of Neuroscience Research Center for Brain Disorders;Medical Research Council Senior Clinical Fellowship(MR/P008747/1 to V.W.);ShanghaiClinical ResearchCenter for Mental Health(19MC1911100 to T.-F.Y.). 摘　　要：Addiction is a major public-health crisis associated with significant disability and mortality.Although various pharmacological and behavioral treatments are currently available,the clinical efficacy of these treatments is limited.Given this situation,there is a growing interest in finding an effective neurosurgical treatment for addiction.First,we discuss the use of ablative surgery in treating addiction.We focus on the rise and fall of nucleus accumbens ablation for addiction in China.Subsequently,we review recent studies that have explored the efficacy and safety of deep-brain-stimulation treatment for addiction.We conclude that neurosurgical procedures,particularly deep-brain stimulation,have a potentially valuable role in the management of otherwise intractable addictive disorders.Larger well-controlled clinical trials,however,are needed to assess clinical efficacy and safety.We end by discussing several key issues involved in this clinical field and identifying some areas of progress. 关键词：drug ADDICTION PSYCHOSURGERY ABLATIVE surgery deep-brain stimulation medical ETHICS

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Neurosurgical treatment for addiction:lessons from an untold story in China and a path forward

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