维普中文期刊产品整合服务

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China

查看全文 作　　者：Zhiliang [1,2]Hu;Ci [2,3]Song;Chuanjun [4]Xu;Guangfu [2,3]Jin;Yaling [1]Chen;Xin [2]Xu;Hongxia [2,3]Ma;Wei [5]Chen;Yuan [6]Lin;Yishan [7]Zheng;Jianming [2]Wang;Zhibin [1]Hu;Yongxiang [1]Yi;Hongbing [2,3]Shen 高影响力作者 机构地区：[1]Nanjing Infectious Disease Center,the Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing 210003,China;[2]Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing 211166,China;[3]State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing 211166,China;[4]Department of Radiology,the Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing 210003,China;[5]Department of Clinical Research Center,the Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing 210003,China;[6]Department of Maternal,Child and Adolescent Health,School of Public Health,Nanjing Medical University,Nanjing 211166,China;[7]Department of Critical Medicine,the Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing 210003,China高影响力机构 出　　处：《Science China(Life Sciences)》索引2020年第63卷第5期,共6页高影响力期刊 基　　金：supported by the project of Jiangsu province medical youth talent(QNRC2016059);Nanjing medical science and technique development foundation(ZKX17040 and YKK18153);the National Natural Science Foundation of China(81903382);Cheung Kong Scholars Program of China。 摘　　要：Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. 关 键 词：COVID-19 asymptomatic infections close contact China
相关文献

参考文献(15)

引证文献(86)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费