HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation

查看全文 作　　者：Chao [1,7]Yang;Wenjin [1,7]Shen;Lianming [1,7]Yang;Yun [1]Sun;Xibao [1]Li;Minyi [1]Lai;Juan [1]Wei;Chaojun [3]Wang;Yingchao [2]Xu;Faqiang [4]Li;Shan [1]Liang;Chengwei [1]Yang;Shangwei [5]Zhong;Ming [2,6]Luo;Caiji [1]Gao

机构地区：[1]Guangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,South China Normal University,Guangzhou 510631,China;[2]Guangdong Provincial Key Laboratory of Applied Botany,Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement,South China Botanical Garden,Core Botanical Gardens,Chinese Academy of Sciences,Guangzhou 510650,China;[3]College of Life Sciences,Leshan Normal University,Leshan 614004,China;[4]College of Life Sciences,South China Agricultural University,Guangzhou 510642,China;[5]School of Advanced Agricultural Sciences and School of Life Sciences,Peking University,100871 Beijing,China;[6]Center of Economic Botany,Core Botanical Gardens,Chinese Academy of Sciences,Guangzhou 510650,China;[7]These authors contributed equally to this article

出　　处：《Molecular Plant》索引2020年第13卷第3期,共17页

基　　金：supported by grants from the National Natural Science Foundation of China(31900231);National Science Foundation of Guangdong Province(2018A030310505)to C.Y.;the National Natural Science Foundation of China(31870171 and 31671467),toC.G.;the Youth Innovation Promotion Association,Chinese Academy of Sciences(2017399);the National Key R&D Program of China(2019YFC1711102);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA13020500)to M.L.,and the National Natural Science Foundation of China(31701246)to W.S. 摘　　要：Light is arguably one of the most important environmental factors that determines virtually all aspects of plant growth and development,but the molecular link between light signaling and the autophagy pathway has not been elucidated in plants.In this study,we demonstrate that autophagy is activated during light-to-dark conversion though transcriptional upregulation of autophagy-related genes(ATGs).We showed that depletion of the ELONGATED HYPOCOTYL 5(HY5),a key component of light signaling,leads to enhanced autophagy activity and resistance to extended darkness and nitrogen starvation treatments,contributing to higher expression oiATGs.HY5 interacts with and recruits HISTONE DEACETYLASE 9(HDA9)to ATG5 and ATG8e loci to repress their expression by deacetylation of the Lys9 and Lys27 of histone 3.Furthermore,we found that both darkness and nitrogen depletion induce the degradation of HY5 via 26S proteasome and the concomitant disassociation of HDA9 from ATG5 and ATG8e loci,leading to their depression and thereby activated autophagy.Genetic analysis further confirmed that HY5 and HDA9 act synergistically and function upstream of the autophagy pathway.Collectively,our study unveils a previously unknown transcriptional and epigenetic network that regulates autophagy in response to light-to-dark conversion and nitrogen starvation in plants. 关键词：AUTOPHAGY histone acetylation HY5 HDA9 light-to-dark shift nitrogen starvation

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HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation

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