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Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling

查看全文 作　　者：Miaomiao [2]Hao;Qiong [1]Tang;Banghua [1]Wang;Yisheng [3]Li;Jieqiong [1]Ding;Mingyue [2]Li;Min [1]Xie;Haili [1]Zhu 高影响力作者 机构地区：[1]Research Center of Basic Medical Sciences,Department of Physiology,School of Basic Medical Sciences,Hubei University of Science and Technology,Xianning 437100,China;[2]School of Pharmacy,Hubei University of Science and Technology,Xianning 437100,China;[3]Department of Radiology,Affiliated Hospital of Hubei University of Science and Technology,Xianning 437100,China高影响力机构 出　　处：《Acta Biochimica et Biophysica Sinica》索引2020年第52卷第3期,共10页高影响力期刊 基　　金：supported by the grants from the Research Project of Key Subject Pharmacy(Nos.2019-20YZ04,2018-19XYZ04);the Research Project of Hubei Provincial Department of Education(No.B2018174);Hubei University of Science and Technology Program(No.BK201804). 摘　　要：Bone cancer pain(BCP)is induced by primary bone cancer and secondary bone metastasis.During BCP pathogenesis,activated spinal astrocytes release proinflammatory cytokines,which participate in pain information transmission.In this study,we found that BCP rats showed disruption of trabecular bone structure,mechanical allodynia,and spinal inflammation.Moreover,reduced adenosine monophosphate-activated protein kinase(AMPK)activity,increased mitochondrial fission-associated protein Drp1 GTPase activity accompanied by the dysfunction of mitochondrial function,and abnormal BAX and Bcl-2 expression were found in the spinal cord of BCP rats.Notably,these alterations are reversed by resveratrol(Res)administration.Cell experiment results demonstrated that Res promotes mitochondrial function by activating AMPK,decreasing Drp1 activity,and inhibiting tumor necrosis factor-cα-induced mitochondrial membrane potential reduction.Taken together,these results indicate that Res suppresses BCP in rats by attenuation of the inflammatory responses through the AMPK/Drp1 signaling pathway. 关 键 词：bone cancer PAIN RESVERATROL SPINAL ASTROCYTE AMPK Drp1
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