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Bacteriophages and Lysins in Biofilm Control

查看全文 作　　者：Marzanna Lusiak-[1]Szelachowska;Beata Weber-[1,2]Dabrowska;Andrzej [1,2]Gorski 高影响力作者 机构地区：[1]Bacteriophage Laboratory,Hirszfeld Institute of Immunology and Experimental Therapy,Polish Academy of Sciences(HIIET PAS),R.Weigla 12,53-114 Wroclaw,Poland;[2]Phage Therapy Unit,Hirszfeld Institute of Immunology and Experimental Therapy,Polish Academy of Sciences(HIIET PAS),R.Weigla 12,53-114 Wroclaw,Poland高影响力机构 出　　处：《Virologica Sinica》索引2020年第35卷第2期,共9页高影响力期刊 摘　　要：To formulate the optimal strategy of combatting bacterial biofilms,in this review we update current knowledge on the growing problem of biofilm formation and its resistance to antibiotics which has spurred the search for new strategies to deal with this complication.Based on recent findings,the role of bacteriophages in the prevention and elimination of biofilm-related infections has been emphasized.In vitro,ex vivo and in vivo biofilm treatment models with single bacteriophages or phage cocktails have been compared.A combined use of bacteriophages with antibiotics in vitro or in vivo confirms earlier reports of the synergistic effect of these agents in improving biofilm removal.Furthermore,studies on the application of phage-derived lysins in vitro,ex vivo or in vivo against biofilm-related infections are encouraging.The strategy of combined use of phage and antibiotics seems to be different from using lysins and antibiotics.These findings suggest that phages and lysins alone or in combination with antibiotics may be an efficient weapon against biofilm formation in vivo and ex vivo,which could be useful in formulating novel strategies to combat bacterial infections.Those findings proved to be relevant in the prevention and destruction of biofilms occurring during urinary tract infections,orthopedic implant-related infections,periodontal and peri-implant infections.In conclusion,it appears that most efficient strategy of eliminating biofilms involves phages or lysins in combination with antibiotics,but the optimal scheme of their administration requires further studies. 关 键 词：ANTIBIOTICS BACTERIOPHAGES BIOFILM CHRONIC DISEASES Lysins
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