Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive stimuli-induced depression

查看全文 作　　者：Yun-Wei [1]Fu;Yan-Fang [2]Peng;Xiao-Dan [1]Huang;Yan [1]Yang;Lu [1]Huang;Yue [1]Xi;Zheng-Fang [1]Hu;Song [3]Lin;Kwok-Fai [1,4,5,6,7]So;Chao-Ran [1,4,5,6]Ren

机构地区：[1]Guangdong-Hongkong-Macao Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China;[2]Aier Eye Institute,Changsha,Hunan Province,China;[3]Department of Physiology,School of Medicine,Jinan University,Guangzhou,Guangdong Province,China;[4]Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China;[5]Center for Brain Science and Brain-Inspired Intelligence,Guangdong-Hong Kong-Macao Greater Bay Area,Guangzhou,Guangdong Province,China;[6]Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China;[7]Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences,The University of Hong Kong,Hong Kong Special Administrative Region,China

出　　处：《Neural Regeneration Research》索引2021年第16卷第3期,共7页

基　　金：supported by the National Natural Science Foundation of China,Nos.31900825(to SL),31922030(to CRR),31771170(to CRR);Science and Technology Program of Guangdong Province of China,No.2018B030334001(to CRR);Science and Techology of Guangzhou of China,No.202007030012(to CRR);Guangdong Special Support Program of China,No.2017TQ04R173(to CRR);Pearl River S&T Nova Program of Guangzhou Province of China,No.201806010198(to CRR);Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory of China,No.2018GZR110102002(to KFS)。 摘　　要：Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied.In this investigation,we established mouse models of depression using aversive stimuli including exposure to fox urine,air puff and foot shock and physical restraint.Concurrently,we administered 5 mg/kg per day Lycium barbarum polysaccharide-glycoprotein to each mouse intragastrically for the 28 days.Our results showed that long-term exposure to aversive stimuli significantly enhanced depressive-like behavior evaluated by the sucrose preference test and the forced swimming test and increased anxietylike behaviors evaluated using the open field test.In addition,aversive stimuli-induced depressed mice exhibited aberrant neuronal activity in the lateral habenula.Importantly,concurrent Lycium barbarum polysaccharide-glycoprotein treatment significantly reduced these changes.These findings suggest that Lycium barbarum polysaccharide-glycoprotein is a potential preventative intervention for depression and may act by preventing aberrant neuronal activity and microglial activation in the lateral habenula.The study was approved by the Jinan University Institutional Animal Care and Use Committee(approval No.20170301003)on March 1,2017. 关键词：aversive stimuli behaviors DEPRESSION immune response inflammation lateral habenula Lycium barbarum polysaccharide mice MICROGLIA NEURON

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Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive stimuli-induced depression

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