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Prognostic value of pretreatment contrast-enhanced computed tomography in esophageal neuroendocrine carcinoma: A multicenter follow-up study

查看全文 作　　者：Yue [1]Zhou;Ping [1]Hou;Kai-Ji [1]Zha;Feng [2]Wang;Kun [3]Zhou;Wei [2]He;Jian-Bo [1]Gao 高影响力作者 机构地区：[1]Department of Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China;[2]Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China;[3]Department of Thoracic Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2020年第26卷第31期,共14页高影响力期刊 基　　金：Supported by the National Natural Science Foundation of China,No.81671682;Medical Science and Technology Project of Henan Province,No.201602012. 摘　　要：BACKGROUND The rare incidence of esophageal neuroendocrine carcinoma(NEC)and limited treatment experience result in insufficient clinical observations and unsuitable guidelines for its management.AIM To investigate the prognostic value of pretreatment contrast-enhanced computed tomography(CT)characteristics in patients with esophageal NEC.METHODS Seventy-seven esophageal NEC patients who received contrast-enhanced CT at two hospitals were enrolled in this study from June 2014 to December 2019.The clinical features and image characteristics were recorded accordingly.Univariate survival analysis was performed using the Kaplan-Meier method and log-rank test,and multivariate analysis was carried out with a Cox proportional hazards model.RESULTS The multivariate analysis performed using the Cox proportional hazards model showed that N stage,adjuvant chemotherapy,and degree of enhancement were independent prognostic factors for overall survival(OS).Meanwhile,adjuvant chemotherapy was an independent prognostic factor for progression-free survival(PFS).The hazard ratios(HRs)of N stage,adjuvant chemotherapy,and degree of enhancement(mild vs moderate/marked)for OS were 0.426(P=0.024),3.862(P=0.006),and 2.169/0.809(P=0.037),respectively.The HR of adjuvant chemotherapy for PFS was 6.432(P<0.001).Adjuvant chemotherapy was significantly associated with degree of enhancement(P=0.018).CONCLUSION Adjuvant chemotherapy is an independent prognostic factor for OS and PFS.Additionally,N stage and degree of enhancement are prognostic factors for OS in patients with esophageal NEC. 关 键 词：Esophageal neuroendocrine carcinoma Computed tomography Prognosis SURVIVAL FOLLOW-UP Adjuvant chemotherapy
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