Tumor microenvironment responsive drug delivery systems

查看全文 作　　者：Qunye [1]He;Jun [1]Chen;Jianhua [1]Yan;Shundong [1]Cai;Hongjie [1]Xiong;Yanfei [3]Liu;Dongming [4]Peng;Miao [2]Mo;Zhenbao [1]Liu

机构地区：[1]Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China;[2]Department of Urology,Xiangya Hospital,Central South University,Changsha 410008,China;[3]School of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China;[4]School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China

出　　处：《Asian Journal of Pharmaceutical Sciences》索引2020年第15卷第4期,共33页

基　　金：Supported by the Huxiang Young Talent Program of Hunan Province(2018RS3005);The Project of Innovation-driven Plan in Central South University(2020CX048);Hunan Provincial Natural Science Foundation of China(2019JJ60071,2020JJ4680);the Shenghua Yuying Project of Central South University,the Hunan Provincial Postgraduate Research and Innovation Project(CX20190242);Postgraduate Independent Exploration and Innovation Project of Central South University(2019zzts1017,2019zzts750);the Key Research Fund of Hunan Provincial Education Department(18A211). 摘　　要：Conventional tumor-targeted drug delivery systems(DDSs)face challenges,such as unsatisfied systemic circulation,low targeting efficiency,poor tumoral penetration,and uncontrolled drug release.Recently,tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dilemmas.With the introduction of several additional functionalities,the properties of these smart DDSs including size,surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting,and eventually achieve desired drug release for an optimized therapeutic efficiency.This review highlights the recent research progresses on smart tumor environment responsive drug delivery systems for targeted drug delivery.Dynamic targeting strategies and functional moieties sensitive to a variety of tumor cellular stimuli,including pH,glutathione,adenosine-triphosphate,reactive oxygen species,enzyme and inflammatory factors are summarized.Special emphasis of this review is placed on their responsive mechanisms,drug loading models,drawbacks and merits.Several typical multi-stimuli responsive DDSs are listed.And the main challenges and potential future development are discussed. 关键词：Cancer therapy Stimuli responsive Dynamic targeting Drug delivery system Controlled release

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Tumor microenvironment responsive drug delivery systems

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