Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing

查看全文 作　　者：Guiting [1]Liu;Ziting [1]Bao;Jun [1,2]Wu

机构地区：[1]Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province,School of Biomedical Engineering.Sun Yat-sen University,Guangzhou 510006,China;[2]Research Institute of Sun Yat-sen University in Shenzhen,Shenzhen 518057,China

出　　处：《Chinese Chemical Letters》索引2020年第31卷第7期,共5页

基　　金：the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX10301402);International Cooperation and Exchange of the National Natural Science Foundation of China(No.51820105004);Science and Technology Program of Guangzhou(No.201707010094);Guangdong Innovative and Entrepreneurial Research Team Program(Nos.2013S086 and 2016ZT06S029);Science and Technology Planning Project of Shenzhen(Nos.JCYJ20170307141438157 and JCYJ20180307163534533);Fundamental Research Funds for the Central Universities(No.191gpy209)。 摘　　要：Baicalin,extracted from traditional Chinese medicine Scutellaria baicalensis Georg,possesses multiple pharmacological activities and has great potential for chronic skin wound repair.However,the poor solubility and lack of suitable vehicles greatly limit its further application.Herein,we proposed a convenient and robust strategy,employing PBS solution as solvent,to enhance the solubility of baicalin.Furthermore,we constructed injectable baicalin/F127 hydrogels to study their application in skin wound treatment.The composition and temperature sensitivity of baicalin/Pluronic®F-127 hydrogels were confirmed by FTIR and rheological testing,respectively.In vitro release measurement indicated that the first order model was best fitted with the release profile of baicalin from hydrogel matrix.Besides,MTT assay,AO/EO staining assay as well as hemolytic activity test revealed the excellent cytocompatibility of baicalin/F127 hydrogels.Antioxidant activity assay demonstrated the cytoprotective activity of baicalin/F127 hydrogels against reactive oxygen species(ROS).Furthermore,the in vivo experiments exhibited the ability of baicalin/F127 hydrogel to accelerate wound healing.In conclusion,this novel injectable baicalin/F127 hydrogel should have bright application for chronic wound treatment. 关键词：Wound healing HYDROGEL BAICALIN Antioxidant INJECTABLE

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Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing

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