A Programmable Hybrid DNA Nanogel for Enhanced Photodynamic Therapy of Hypoxic Glioma

查看全文 作　　者：Ye [1]Yuan;Huiting [1]Zhao;Yunhua [1]Guo;Jianpu [1]Tang;Chunxia [1]Liu;Linghui [1]Li;Chi [1]Yao;Dayong [1]Yang

机构地区：[1]Key Laboratory of Systems Bioengineering(MOE),Frontier Science Center for Synthetic Biology,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China

出　　处：《Transactions of Tianjin University》索引2020年第26卷第6期,共8页

基　　金：supported by National Natural Science Foundation of China(Nos.21704074,21621004);Tianjin Natural Science Foundation(Basic Research Plan,Nos.18JCJQJC47600,19JCQNJC02200). 摘　　要：Photodynamic therapy(PDT)is a promising cancer therapy due to the evident advantages of a rapid curative eff ect,minimal or non-invasiveness,and circumvention of drug resistance.However,the hydrophobicity of photosensitizers and the hypoxic tumor microenvironment in solid tumors reduce the therapeutic eff ect of PDT immensely.Herein,we construct a programmable hybrid mesoporous silica nanoparticle/DNA nanogel(H-DNA nanogel)for enhanced PDT.The H-DNA nanogel is constituted with a virus-like mesoporous silica nanoparticle(VMSN)as the core to provide an appropriate nano-interface and a self-assembly programmable DNA hydrogel layer based on rolling circle amplifi cation(RCA)as the shell.Two kinds of G-quadruplex structures inserted with a hemin and zinc phthalocyanine(ZnPc)photosensitizer are introduced into the H-DNA nanogel by base pairing.The two modules of G-quadruplex structure work as an oxygen supplement in the hypoxic tumor microenvironment and increase the yield of singlet oxygen,respectively.Our hybrid DNA nanogel system provides a modular platform for effi cient cancer PDT and has great potential in the broader biomedical fi eld. 关键词：DNA nanogel Rolling circle amplifi cation Mesoporous silica nanoparticle Photodynamic therapy

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A Programmable Hybrid DNA Nanogel for Enhanced Photodynamic Therapy of Hypoxic Glioma

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