Inflammatory bowel disease:Therapeutic limitations and prospective of the stem cell therapy

查看全文 作　　者：Rangnath [1]Mishra;Punita [2,3,4]Dhawan;Anand S [1]Srivastava;Amar B [2,3,4]Singh

机构地区：[1]Institute of Stem Cell Therapy and Research,San Diego,CA 92122,United States;[2]Department of Biochemistry and Molecular Biology,University of Nebraska Medical Center,Omaha,NE 68118,United States;[3]Fred and Pamela Buffett Cancer Center,Omaha,NE 68118,United States;[4]VA Nebraska-Western Iowa Health Care System,Omaha,NE 68118,United States

出　　处：《World Journal of Stem Cells》索引2020年第12卷第10期,共17页

基　　金：Department of Veterans Affairs,No.2I01BX002761-05 and No.2I01BX002086-06A1;The National Institutes of Health,No.1R01DK124095-01A1 and No.1R21CA216746-01A1. 摘　　要：Inflammatory bowel disease(IBD),consisting primarily of ulcerative colitis and Crohn’s disease,is a group of debilitating auto-immune disorders,which also increases the risk of colitis-associated cancer.However,due to the chronic nature of the disease and inconsistent treatment outcomes of current anti-IBD drugs(e.g.,approximately 30%non-responders to anti-TNFαagents),and related serious side effects,about half of all IBD patients(in millions)turn to alternative treatment options.In this regard,mucosal healing is gaining acceptance as a measure of disease activity in IBD patients as recent studies have correlated the success of mucosal healing with improved prognosis.However,despite the increasing clinical realization of the significance of the concept of mucosal healing,its regulation and means of therapeutic targeting remain largely unclear.Here,stemcell therapy,which uses hematopoietic stem cells or mesenchymal stem cells,remains a promising option.Stem cells are the pluripotent cells with ability to differentiate into the epithelial and/or immune-modulatory cells.The overreaching concept is that the stem cells can migrate to the damaged areas of the intestine to provide curative help in the mucosal healing process.Moreover,by differentiating into the mature intestinal epithelial cells,the stem cells also help in restoring the barrier integrity of the intestinal lining and hence prevent the immunomodulatory induction,the root cause of the IBD.In this article,we elaborate upon the current status of the clinical management of IBD and potential role of the stem cell therapy in improving IBD therapy and patient’s quality of life. 关键词：Crohn′s disease Ulcerative colitis Mesenchymal stem cells Hematopoietic stem cells Mucosal healing

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Inflammatory bowel disease:Therapeutic limitations and prospective of the stem cell therapy

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