Thymosin alpha 1:A comprehensive review of the literature

查看全文 作　　者：Asimina [1]Dominari;Donald Hathaway [1]III;Krunal [1]Pandav;Wanessa [1]Matos;Sharmi [1]Biswas;Gowry [1]Reddy;Sindhu [1]Thevuthasan;Muhammad Adnan [1]Khan;Anoopa [1]Mathew;Sarabjot Singh [1]Makkar;Madiha [1]Zaidi;Michael Maher Mourad [1]Fahem;Renato [1]Beas;Valeria [1]Castaneda;Trissa [1]Paul;John [1]Halpern;Diana [1]Baralt

机构地区：[1]Division of Research and Academic Affairs,Larkin Health System,South Miami,FL 33143,United States

出　　处：《World Journal of Virology》索引2020年第9卷第5期,共12页

摘　　要：Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. 关键词：Thymosin alpha 1 THYMALFASIN Immunomodulating T lymphocytes Infectious diseases Immune deficiency Oxidative damage

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Thymosin alpha 1:A comprehensive review of the literature

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