Organoid technology for tissue engineering

查看全文 作　　者：Juan [1]He;Xiaoyu [1]Zhang;Xinyi [1]Xia;Ming [1]Han;Fei [1]Li;Chunfeng [1]Li;Yunguang [1]Li;Dong [1,2]Gao

机构地区：[1]State Key Laboratory of Cell Biology,Shanghai Key Laboratory of Molecular Andrology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China;[2]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Journal of Molecular Cell Biology》索引2020年第12卷第8期,共11页

基　　金：This study was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020905 and XDB19000000);the National Key Research and Development Program of China(2017YFA0505500 and 2018ZX10302207-00*-001);the Basic Frontier Science Research Program of Chinese Academy of Sciences(ZDBS-LYSM015);the National Natural Science Foundation of China(81830054 and 81772723). 摘　　要：For centuries,attempts have been continuously made to artificially reconstitute counterparts of in vivo organs from their tissues or cells.Only in the recent decade has organoid technology as a whole technological field systematically emerged and been shown to play important roles in tissue engineering.Based on their self-organizing capacities,stem cells of versatile organs,both harvested and induced,can form 3D structures that are structurally and functionally similar to their in vivo counterparts.These organoid models provide a powerful platform for elucidating the development mechanisms,modeling diseases,and screening drug candidates.In this review,we will summarize the advances of this technology for generating various organoids of tissues from the three germ layers and discuss their drawbacks and prospects for tissue engineering. 关键词：organoid tissue engineering 3D culture

相关文献

参考文献（153）
引证文献（4）
耦合文献（39）

参考文献(153)

引证文献(4)

耦合文献(39)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Organoid technology for tissue engineering

参考文献(153)

引证文献(4)

耦合文献(39)

用户提示